Han Liu · Orrington Lunt Professor · Director, Center for Foundation Models & Generative AI · Northwestern University

Scientific intelligence / MAGICS Lab

NORTHWESTERN UNIVERSITY

From discovery
to invention.

We develop AI that reasons about the world, designs interventions, and learns from experiments.

Our ambition: make scientific experience improve both what AI understands and what it can help us build.

Scientific intelligence: from discovery to invention Our research connects six steps: reason, model, design, experiment, verify, and learn. Verifiable experience feeds back into the next scientific question or engineering design. SCIENTIFICDiscovery↕Invention REASONMODELDESIGNEXPERIMENTVERIFYLEARN EXPERIENCE → BETTER DECISIONS
One research agenda.
Learning grounded in the physical world.

The research agenda

Three frontiers. One learning cycle.

Agents choose the next step. Models anticipate its consequences. Experiments test it against the world.

01 /Learn from experience

Self-improving
Scientific Agents

How can AI become better at research through experience? We study memory, reasoning, adaptation, and tool use to help agents improve their hypotheses, plans, and decisions from evaluated outcomes.

Explore the foundations →
03 /Close the loop

Autonomous
Laboratories

We develop systems that connect scientific agents with simulation, robotics, and automated experiments. The goal: a Design–Build–Test–Learn cycle that makes each measured outcome useful for the next decision.

Explore the systems →

The compounding opportunity

Understand the world.
Learn what to build.

Discovery creates knowledge. Invention puts it to the test. We study how AI can connect both, turning measured outcomes into better questions, designs, and experiments.

From discovery to invention →
01 / DISCOVERYWhat is true?
  1. Hypothesize
  2. Predict
  3. Experiment
  4. Learn

Shared intelligence. Verifiable experience.
Better evidence for the next decision.

02 / INVENTIONWhat can we build?
  1. Design
  2. Build
  3. Test
  4. Improve

From ideas to scientific infrastructure

Built across disciplines. Connected to the world.

CFMGCenter for Foundation Models
and Generative AI

A home for the next generation
of foundation models.

Directed by Han Liu, Northwestern’s CFMG connects foundational advances in machine intelligence with science and engineering, bringing researchers together around models, reasoning, and discovery.

Explore the center ↗

DREAM

AI-POWERED CLOUD LAB

An NSF-supported cloud laboratory in development, connecting protein design, AI, robotics, and automated experimentation. Han Liu serves as Co-PI and AI lead.

Inside the initiative ↗

TEMPI

THE DYNAMIC UNIVERSE

Han Liu co-leads a scientific foundation-model project within the NSF–Simons SkAI Institute, learning from astronomical time-series data.

Explore the project ↗

Build the next generation
of scientific intelligence.

We welcome students, scientific collaborators, industry partners, and investors who share an interest in reasoning agents, scientific models, and experimental systems.

Start a conversation

Reading Group

Our weekly reading group explores ideas that may shape the next generation of machine and scientific intelligence — from the foundations of reasoning, memory, and world models to agents that interact with tools, simulations, and the physical world. We use the group not simply to review papers, but to identify emerging paradigms, formulate new research questions for scientific discovery.

Get In Touch

Department of Computer Science
Mudd Hall 3119
Northwestern University
Evanston, IL 60201
Phone: +1 847 491 2793
Email: hanliu@northwestern.edu